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Metformin and Oligonol: A Winning Combination for Health?

J SALAS - RUSHFORD MD

Aging is a complex process influenced by a combination of genetic, environmental, and lifestyle factors. At the cellular level, aging is driven by the accumulation of damage to DNA, proteins, and other macromolecules over time. This damage can result from oxidative stress, which occurs when there is an imbalance between the production of free radicals and the body's ability to neutralize them. Additionally, telomeres, the protective caps at the ends of chromosomes, shorten with each cell division, eventually leading to cellular senescence or the loss of a cell's ability to divide and function properly. Other contributing factors include chronic inflammation, mitochondrial dysfunction, and the decline in the body's ability to repair and regenerate tissues. Together, these processes lead to the gradual deterioration of physiological functions and an increased susceptibility to age-related diseases.


Metformin is a widely used medication primarily prescribed for the management of type 2 diabetes. It belongs to a class of drugs known as biguanides and works by reducing glucose production in the liver, improving insulin sensitivity, and enhancing glucose uptake by muscles. This helps to lower blood sugar levels and maintain them within a normal range. Metformin is often favored due to its effectiveness, low risk of causing hypoglycemia (low blood sugar), and potential benefits in weight management. Additionally, it has been studied for its potential anti-aging effects and its role in reducing the risk of certain cancers and cardiovascular diseases.


The TAME (Targeting Aging with Metformin) study is a groundbreaking clinical trial aimed at exploring whether metformin, a common diabetes medication, can delay the onset of age-related diseases such as heart disease, cancer, and dementia. The trial involves over 3,000 participants aged 65-79 and is conducted across 14 research institutions. Metformin has shown promise in animal studies for delaying aging and may influence fundamental aging factors in humans. The goal is to establish aging as a treatable condition, potentially leading to a paradigm shift in how age-related diseases are managed.





Polyphenols, naturally occurring compounds found in a variety of plant-based foods such as fruits, vegetables, tea, and red wine, have garnered attention for their potential anti-aging properties. These compounds exhibit powerful antioxidant and anti-inflammatory effects, which help combat oxidative stress and inflammation—two key contributors to the aging process. By neutralizing free radicals and reducing inflammation, polyphenols can protect cells from damage and support overall cellular health. Additionally, polyphenols have been shown to enhance mitochondrial function, promote autophagy (the body's process of cleaning out damaged cells), and improve immune function, all of which contribute to healthier aging and a reduced risk of age-related diseases. Incorporating polyphenol-rich foods into one's diet may therefore help slow down the aging process and improve longevity.

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Oligonol is a patented, low-molecular-weight polyphenolic extract derived from lychee fruit (85%) and green tea (15%). It is known for its excellent absorption and multiple anti-aging benefits. Oligonol addresses three major causes of aging: poor blood circulation, oxidative stress, and inflammation. Clinical studies have shown that Oligonol can support healthy post-meal blood glucose and lipid levels, reduce visceral fat, lessen skin wrinkles and brown spots, decrease fatigue, and improve endurance. Due to its powerful antioxidant and anti-inflammatory properties, Oligonol is often referred to as the "All-Natural Fountain of Youth"

 

 

 

 

 

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